Lose fat. Keep what you've built.

Fat loss is a multi-step process, and most approaches only address one step. AOD-9604 targets the first step — mobilizing stored fat by activating beta-3 adrenergic receptors on fat cells. But mobilized fat still needs to be processed by the liver and converted into energy. That's where Lipo-B comes in.

AOD-9604 breaks fat free from storage. It activates lipolysis at the receptor level, signaling fat cells to release their stored fatty acids into the bloodstream. It simultaneously inhibits the enzymes that create new fat storage. This dual mechanism addresses the metabolic bottleneck that keeps stubborn fat in place despite diet and exercise.

Lipo-B ensures the liberated fat gets processed efficiently. The MIC complex (Methionine, Inositol, Choline) supports the liver's ability to metabolize fat rather than recirculate it. Choline specifically supports VLDL assembly — the transport mechanism that moves fat out of the liver. Without adequate lipotropic support, mobilized fat can end up back in storage.

The B12 component powers the entire process. Fat metabolism is energy-intensive, and B12 is a critical cofactor in the metabolic pathways that convert fatty acids into ATP. Patients often report a noticeable increase in sustained energy as their body becomes more efficient at burning fat for fuel.

The combined effect: AOD-9604 opens the gates, and Lipo-B makes sure the body actually uses what comes out. This is why patients on the Lean & Burn protocol at Uplevel Bio often see better results than those using either compound alone.

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Weeks 1–2: Improved energy levels from the Lipo-B component, particularly if you were B12 deficient. Subtle shifts in how your body feels — less bloating, more alertness. Fat loss isn't visible yet but the metabolic shift is beginning. Week 4: Clothes start fitting differently. Many patients notice changes in stubborn areas — abdomen, flanks, or thighs — that previously resisted diet and exercise. Energy continues to improve, and workout performance often increases. Week 8: Visible body composition changes. Fat loss is clearly measurable, and the body begins to look leaner and more defined. Patients often describe this as the point where other people start noticing the difference. Week 12: Full protocol benefits. Significant fat reduction, improved muscle definition (especially when combined with resistance training), sustained energy levels, and a metabolism that's functioning more efficiently overall. Many patients continue on a maintenance protocol.

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Lean & burn starts at $210 / month. You'll see your exact total — including medical processing and shipping — at checkout before you pay. See the live total →

What's included with every program:

• Medical review by the prescribing clinical team
• Patient care team access throughout your program
• Connected health tracking (Oura, Whoop, Apple Health)
• Member resources and educational guides
• Two-day shipping from a licensed 503A compounding pharmacy
• One order — no auto-renewal

If the clinical team declines your application, the full amount is refunded to your card within 5–7 business days.

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Step 1 — Pick your protocol. Lean & Burn is designed for focused fat loss without stimulants. Step 2 — Quick health intake. 5-minute online questionnaire. No office visit required. Step 3 — Provider review. Licensed physician reviews within 24 hours. Step 4 — Delivered to your door. two-day shipping in temperature-controlled packaging.

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