Compound
Everything we've written on DSIP — 6 articles covering the mechanism, the evidence, comparisons, and practical considerations.
6 articles
Sleep and recoveryAnxiety and sleep peptides compared — Selank, DSIP, oxytocin, low-dose SermorelinYou don't fall asleep so much as lie there cataloguing. The ceiling, the ambient hum of whatever your brain decided is unresolved, the fact that you know you need to sleep and that knowledge is precisely what's making it harder. You wake at 3 a.m. for no external reason and then spend an hour not-quite-conscious, not-quite-asleep, circling. The next day arrives already thinned out and the anxiety that kept you up is worse for the sleep debt, and the sleep debt is worse for the anxiety. The loop has its own particular logic and it's immune to basic advice.9 min readSleep and recoveryWhat people are reporting about DSIPThis article summarizes experiences reported in public online communities including Reddit, longevity forums, and discussion boards. We are not advocating human use of any compound discussed here. Many of the peptides discussed are not FDA-approved for the uses described, and some are explicitly not approved for human or veterinary use. What follows is a synthesis of what people have reported, presented to give readers context on the public conversation — not as guidance, not as evidence of safety or efficacy, and not as a recommendation. Decisions about any compound should be made with a qualified prescribing provider after a full medical evaluation.8 min readSleep and recoveryDSIP and the deep-sleep story — what the original peptide research suggestedIt's 1974 in Basel, Switzerland, and a rabbit is asleep. Not naturally asleep — electrically induced into a slow-wave state, its brain oscillating in the long, lazy delta rhythms that characterize the deepest phase of sleep. Marcel Monnier and Guido Schoenenberger are collecting something from the animal: blood drawn from the cerebral venous sinus, the vessel draining the sleeping brain. Their hypothesis is strange by the standards of the time. They believe sleep isn't just a brain state — they believe it might be a circulating signal. Something in the blood of a sleeping animal, they suspect, could make a waking animal sleep.8 min readSleep and recoveryDSIP for sleep, jet lag, and HPA balance — the limited human researchYou land at six in the morning local time after a transatlantic flight and your body is certain it's midnight. The hotel room is perfectly dark and perfectly quiet and you cannot sleep. You're not just tired — you're in the peculiar purgatory of jet lag where exhaustion and wakefulness coexist, where the machinery for sleep is clearly present but something has come loose in the timing mechanism. You lie there for three hours watching the ceiling brighten. By the time you give up and shower, you've been awake for twenty-two hours and feel like you've been awake for thirty.8 min readSleep and recoveryBuilding a peptide approach to sleep — the integrated frameworkYou've done the things. Consistent bedtime, no screens after nine, blackout curtains, cooler room, no alcohol during the week. You've tried melatonin — the large dose that didn't work, then the small dose that helped a little, then the deliberate timing that helped more. You've cut the late dinners. You've tracked the coffee. And sleep is still not the thing you want it to be. Not terribly broken, but not right either. You wake up in the night, or you sleep the hours and don't feel the recovery, or the depth is missing in ways your body knows even when the tracker doesn't catch it cleanly.8 min readSleep and recoveryPeptides for night shift workers — beyond melatonin and caffeineYou finish your shift at seven in the morning. The drive home is in full daylight — bright, direct, summer-morning light hitting your retinas at exactly the wrong time. You get home, pull the blackout curtains, take the melatonin, and lie there in the dark with your nervous system running at eleven o'clock at night energy while the rest of the world is starting its day. You fall asleep around ten-thirty, maybe eleven. You need to be back at eleven p.m. You have roughly eight hours but the sleep you get in them doesn't feel like eight hours. It never does.10 min read